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Gastroenterology Medicine & Research

Morphological Aspects of the Pathogenesis of Gallbladder Cholesterosis

  • Open or CloseMorozov IA1* and Khomeriky SG2

    1Chumakov Federal Scientific Center for Russian Academy of Sciences, Russia

    2Loginov Moscow Clinical Scientific Center, Russia

    *Corresponding author:Morozov IA, Chumakov Federal Scientific Center for Russian Academy of Sciences, Russia

Submission: June 06, 2019 Published: June 17, 2019

DOI: 10.31031/GMR.2019.03.000562

ISSN 2637-7632
Volume3 Issue3


The article presents a new view on the pathogenesis of cholesterosis of the gallbladder, formed on the basis of the morphological study of a large number of gallbladders after cholecystectomy using modern.

Methods: Light and electron microscopy, immunohistochemistry. Essentially new information is given on the structure of the gallbladder wall and its pathomorphosis in the dynamics of the disease. The phenomenon of endocytosis absorption of bile micelles by absorptive epithelial cells and their penetration into their own plate is described for the first time. It is this process that triggers the activation of histiocytes and their transformation into tissue macrophages. For the first time, using immunohistochemistry, it was proved that only macrophages are the phenotypic precursor of foam cells.

Conclusion: The etiological factor of cholesterosis is general disorders of the body’s lipid metabolism and the following changes in the metabolizing properties of absorbent biliary epithelium cells, as well as the synthetic and secretory functions of tissue macrophages.

Keywords: Gallbladder; Cholesterosis; Pathogenesis

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