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Gastroenterology Medicine & Research

Primary Prophylaxis of Variceal Bleeding is Combined Prophylaxis More Effective?

Submission: May 02, 2018; Published: May 15, 2018

DOI: 10.31031/GMR.2018.01.000519

ISSN 2637-7632
Volume1 Issue4


One of the most common and life-threatening complications of portal hypertension is gastrointestinal bleeding secondary to oesophageal varices (OV). Estimates of the annual bleeding risk range from 10%-30% [1,2]. Despite advances in management, mortality remains high; 6-week mortality is around 15%, especially in patients with advanced liver dysfunction. Management is also resource and cost intensive, often requiring intensive care or high dependency unit admission, blood transfusion, vasoconstrictor therapy, endoscopic treatment and antibiotic prophylaxis [1,3].

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