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Abstract

Gerontology & Geriatrics Studies

Correlation Between Depression and Alzheimer’s Biomarkers: Depression may be Considered an Early Biomarker of Alzheimer?

  • Open or CloseSbai O1*, Bejaoui F1 and Perrone L2

    1Laboratory of Transmission, Control and Immunobiology of Infections (LTCII), Pasteur Institute of Tunis, Tunisia

    2Department of Life Sciences, Health and Health Professions, Link Campus University, Italy

    *Corresponding author:Oualid Sbai, Laboratory of Transmission, Control and Immunobiology of Infections (LTCII), LR11IPT02, Pasteur Institute of Tunis, Tunis 1068, Tunisia

Submission: August 29, 2025;;Published: September 18, 2025

DOI: 10.31031/GGS.2025.10.000727

ISSN 2578-0093
Volume 10 Issue 1

Abstract

Depressive symptoms are associated with an increased risk of Alzheimer’s Disease (AD). Some studies have highlighted depression as a possible risk factor while others suggested that depression may be an early manifestation of AD. This mini review explores the association between specific AD biomarker and depression. Plasma amyloid beta (Aβ), phosphorylated-tau, Glial Fibrillary Acidic Protein (GFAP) and neurofilament light chain (NFL) are blood biomarkers for AD. To date, the existing literature in this research field showed that there are several inconsistencies between different studies especially those regarding the association between AD specific marker and depression.

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