Abstract

Rabies is an acute infectious disease caused by the rabies virus and is one of the most common zoonotic diseases in people’s lives. Although rabies is a vaccine-preventable viral disease, however, it is almost 100% fatal once clinical symptoms appear. Rabies Virus (RABV) is a single-stranded, non-segmented, negative-stranded RNA virus belonging to the genus Lyssavirus in the family Rhabdoviridae. With the development of molecular virology, many different types of novel rabies vaccines have been developed. Examples include recombinant weak-virus vaccines, recombinant live-vector vaccines, DNA vaccines, inactivated vaccines, subunit vaccines and virus-like particle vaccines. Since most of the rabies vaccines used in developing countries have the disadvantage that they are too expensive to produce and must be repeated. Therefore, there is a need for new vaccines that are cheaper, more efficient and provide continuous immunization in a single dose.

Keywords:Rabies; Rabies virus; Vaccine