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Abstract

Cohesive Journal of Microbiology & Infectious Disease

In Vitro Evaluation of the Antimicrobial Activity of Solenostemma argel (Harjal) Extract Against Uropathogenic

Submission: September 05, 2024;Published: October 17, 2024

DOI: 10.31031/CJMI.2024.07.000659

ISSN: 2578-0190
Volume7 Issue2

Abstract

Background: Most uropathogenic bacteria exhibit multi-drug resistance, even with antibacterial medicines intended to treat urinary tract infections. These are causing an increasing amount of health and economic loss globally, so regional, national, and international action is required. Therefore, different strategies utilizing bioactive components from conventionally used medicinal plants are needed to address this issue.
Objectives: This study evaluated the in vitro antimicrobial activity of different concentrations of ethanolic Solenostemma argel (Harjal) extraction in the traditional treatment of urinary tract infections.
Methods: A cross-sectional study was done in Shendi Town, River Nile State, at the microbiology laboratory at Shendi University. Fifty samples from both sexes were collected randomly from different clinics in Shendi, from which eight strains of uropathogenic bacteria were isolated and identified using colonial morphology, Gram stain, and biochemical tests. We tested the ethanolic Solenostemma argel (Harjal) extract at concentrations of 100%, 50%, 25%, and 12.5% w/v, using the agar well diffusion method.
Results: Out of a total of 50 clinical specimens confirmed, 22 (44% of them) were men, and 28 (56%) were women. Of the total 50 clinical specimens, 15 (30%) were confirmed as Staphylococcus aureus, 20 (40%) Escherichia coli, 3 (6%) Klebsiella pneumoniae, 2 (4%) Citrobacter, 2 (4%) Enterobacter, 6 (12%) Staphylococcus epidermidis, 1 (2%) Staphylococcus saprophyticus, and 1 (2%) E. fecalies. The extract of Solenostemma argel has promising antibacterial activity against tested uropathogenic bacteria.
Conclusion: The Solenostemma argel possesses a remarkable antimicrobial effect on gram-positive and gram-negative bacteria. Of all extracts, the ethanolic and aqueous extracts of Solenostemma argel were the most active, whereas the aqueous extracts of all plants do not possess significant antibacterial activity both against standard and clinical strains. Ethanolic extracts of Solenostemma argel showed high antibacterial activity against Gram-positive and Gram-negative at low concentrations, whereas they were found to be ineffective at high actions. However, further studies are necessary to find active components in Solenostemma argel extract and to confirm its mechanism of action.

Keywords:Solenostemma argel; Uropathogenic; Antimicrobial activity; Herbal medicine; Bacterial infections

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