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Abstract

Cohesive Journal of Microbiology & Infectious Disease

Preparation of the Dermal Mucoadhesive Film Containing Mupirocin

Submission: November 30, 2019; Published: July 15, 2020

DOI: 10.31031/CJMI.2020.04.000576

ISSN: 2578-0190
Volume4 Issue1

Abstract

Direct drug delivery of the antibiotics to the site of infection has many advantages such as reducing the adverse effect and achieving the minimum inhibitory concentration in the infected tissue. The goal of the study is to formulate the skin patch containing mupirocin as the antibiotic for the local drug delivery to the skin lesions such as burning ulcers on the surface of the skin. The different skin patches with the different polymers as the film former were applied for formulating the patches containing 2% mupirocin as the antibiotics. The patches were fabricated by the different ratio of chitosan, hydroxyl propyl methyl cellulose (HPMC) and polyethylene glycol (PEG) as the film former. The important characteristics of each film such as antibacterial activity, mucoadhesive properties and the release rate of mupirocin from the patches were measured by the in vitro tests. The suitable formulations were selected for the animal test. The results of the in vitro tests showed that the type of the polymer which were applied for the fabrication of the films and the chitosan to HPMC ratio in the structure of the films are the important effective factor on the characteristics of the films such as antibacterial activity and mucoadhesive properties of the patches. Increasing the percentage of the HPMC and chitosan in the structure of the patches caused to increase the mucoadhesive properties of the films. The antibacterial activity for the patches which were fabricated by HPMC as the film former was more than the others. More than 50% of drug was released from the films during 2 hours in all the formulations. Application of chitosan in the structure of the films caused to decrease the release rate of mupirocin from the films. The results of the in vivo tests showed that the most suitable efficacy belonged to the slow release formulations [1-5].

Keywords: Dermal mucoadhesive; Drug delivery systems; Chitosan film; HPMC film-dermal; Ulcers; Mupirocin

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