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Abstract

Cohesive Journal of Microbiology & Infectious Disease

Huge Genetic Inclusion during Conversion of R-Plasmids into MDR Conjugative Plasmids in Multidrug-Resistant Bacteria

  • Open or Close Asit Kumar Chakraborty*

    Department of Biotechnology and Biochemistry, Oriental Institute of Science and Technology, India

    *Corresponding author: Asit Kumar Chakraborty, Department of Biotechnology and Biochemistry, Oriental Institute of Science and Technology, Vidyasagar University, Midnapore-721102, West Bengal, India

Submission: May 24, 2018; Published: July 16, 2018

DOI: 10.31031/CJMI.2018.02.000526

ISSN: 2578-0190
Volume2 Issue1

Abstract

High rate infections and deaths due to multidrug-resistant pathogens have created a horror worldwide. Because MDR bacteria are present in river, sea and air as well as in all household matters, such infections are ubiquitous. Most dangerous step occurred when R-plasmids and integrons (2-9kb) were combined with F’-conjugative plasmid (50-500kb) creating MDR conjugative plasmids that highly donated the mdr genes into household pathogens in the environment. Now 40% of household Escherichia coli and Staphylococcus aureus like Gram (+) and Gram (-) bacteria are ampicillin resistant and also to some extent tetracycline, chloramphenicol, streptomycin, erythromycin, ciprofloxacin, sulfamethoxazole and neomycin resistant.

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