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Abstract
COJ Biomedical Science & Research
A Potential Mechanism for Triggering Cytokine Storm in Covid-19 Patients
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Open or CloseHarald Butterweck and Alfred Weber*
Baxalta Innovations GmbH, Vienna, Austria
*Corresponding author:Alfred Weber, Baxalta Innovations GmbH, Vienna, Austria
Submission: August 29, 2020; Published: September 03, 2020
Volume1 Issue2 September 2020
Abstract
Infection with SARS-CoV-2 can result in severe disease characterized by cytokine storm and systemic inflammation. Despite huge efforts, there is only initial evidence that the humoral immune response and particularly the development of antibodies targeting SARS-CoV-2 nucleoprotein could play a decisive role for disease severity. Here, we present the opinion that severe Covid-19 disease could be co-triggered by anti-SARS-Cov-2 nucleoprotein antibodies, which are cross-reactive with human interleukin-11 and inhibit its anti-inflammatory and tissue protective function.
'Keywords:Autoantibodies; Covid-19; SARS-CoV-2; Cytokine storm; Interleukin-11; Nucleoprotein
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