Abstract

Placental site trophoblastic tumour is an infrequently discerned gestational trophoblastic neoplasm emerging from placental implantation site. Tumefaction may emerge subsequent to gestation at term, spontaneous abortion or a molar pregnancy. Of obscure aetiology, the neoplasm arises due to neoplastic transformation of cytotrophoblastic cells wherein transformed cells differentiate towards intermediate trophoblast. Clinically, irregular vaginal bleeding, menorrhagia, abnormal uterine bleeding, amenorrhea or an enlarged uterus are observed. The infiltrative neoplasm is composed of sheets and aggregates of enlarged, spherical or polyhedral, mononuclear intermediate trophoblastic cells imbued with abundant amphophilic, eosinophilic or clear cytoplasm with irregular cytoplasmic perimeter, pleomorphic, enlarged or convoluted, hyperchromatic nuclei and significant nuclear atypia.

Keywords:Gestational neoplasm; Implantation; Intermediate trophoblast

Abbreviations: β-HCG: Beta Human Chorionic Gonadotropin; FIGO: Federation of Gynaecology and Obstetrics; SMA: Smooth Muscle Actin; PLAP: Placental Alkaline Phosphatase; HPL: Human Placental Lactogen; CT: Computerized Tomography; MRI: Magnetic Resonance Imaging; PET: Positron Emission Tomography