Obscure Gastrointestinal (GI) bleeding, defined by persistent or recurrent GI bleeding with source not identified on bidirectional endoscopy and small bowel radiological imaging accounts for nearly 5% of cases of GI bleeding [1]. Dieulafoy’s lesion is a potentially life-threatening condition wherein persistent caliber submucosal arteriole can bleed torrentially [2]. If there is associated thrombocytopenia, it could be devastating combination. We hereby present a case of obscure overt GI bleeding (Melena) due to Dieulafoy’s lesion in jejunum. She require blood transfusions for the quantum of GI bleeding. She had a rare inherited platelet disorder-Bernard Soulier syndrome [3] with non-ITP thrombocytopenia which was managed using Enteroscopy and APC of the lesion and blood products. We would like to highlight the need to follow a proper approach in managing bleeding tendency with thrombocytopenia to rule out inherited disorders and not blindly labelling it as ITP in a case of thrombocytopenia.

Keywords:Thrombocytopenia; Obscure gastrointestinal; Hemoglobin; glycoproteins