Abstract

To find out the various clinicopathological presentations of gall stone disease with special relation to H. pylori infections of Gall Bladder. Institution based observational study in a tertiary care center. A total of 50 patients were selected who were admitted with the diagnosis of cholelithiasis and planned for cholecystectomy. Gallbladder specimen was then sent for routine H&E stain and additional Giemsa stain. Patients were grouped under two categories based on result of Giemsa stain. Out of which 10% showed the presence of H. pylori in the GB wall specimen. The presence of H. pylori in gall bladder wall was mostly seen in patients depicting chronic cholecystitis features on histopathological examination. Chronic cholecystitis is one of the most common risk factors for development of GBC. And inflammation being an important predisposing factor for development of cancer, could help us establish a relationship between GB cancer and H. pylori. Thus, in areas of high prevalence of GBC, like the gang belt H. pylori should further be evaluated as an etiological agent for the development of gall bladder cancer.

Keywords: H. pylori; Cholelithiasis; Gall bladder cancer (GBC); Cholecystitis