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Significances of Bioengineering & Biosciences

Synthesis, Characterization and Antifungal Activities, Aspergillus Niger, Aspergillus Flavus, Candida Albicans of Novel Schiff Base and Schiff Based Resin

  • Open or CloseNasira LR1*, Akhtar MM1, Aamna B2 and Mohammed KK3

    1M A Kazi Institute of Chemistry, University of Sindh, Pakistan

    2Department of Physics Engineering, Istanbul Technical University, Turkey

    3Faculty of General Nursing, Bioterra University, Romania

    4H E J Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Pakistan

    *Corresponding author: Nasira Liaquat Rajput, M A Kazi Institute of Chemistry, University of Sindh, Jamshoro-76080, Pakistan

Submission: July 21, 2021;Published: September 20, 2021

DOI: 10.31031/SBB.2021.05.000612

ISSN 2637-8078
Volume 5 Issue 3


This work studies the synthesis of a novel Schiff base bis (2- methoxy-1-napthaldehyde) hydrazine hydrate and Schiff based resin poly methylene bis (2- methoxy-1-napthaldehyde) hydrazine hydride via-condensation procedure using with formaldehyde (HCHO) at temperature 70 to 80 °C for 3-4 hours. The synthesized Schiff base BMNHH and resin PMBMNHH were recrystallized from methanol resulting pure compounds. The synthesized compounds were characterized by (CHN), (FT-IR) Thermo Gravimetric Analysis (TGA), EDS analysis and Scanning Electron Microscopy (SEM), Powder X-Ray Diffraction Analysis (XRD). The all results of analytical techniques successfully approved the structure and morphology of newly prepared Schiff base and Schiff based resin. After the characterization the synthesized compounds BMNHH and PMBMNHH was screened against Gram-negative antifungal strains such as, Aspergillus Niger (Gram-negative) Aspergillus flavus (Gram-negative), Candida albicans (Gram-negative) through Agar well diffusion method. The found results conveyed that the tested compounds indicated good sensitivity and enhanced activity against Gram-negative antifungal strains [1,2].

Keywords: Synthesis; Antifungal; Spectroscopy; Condensation; Morphology; Candida albicans

Abbreviations: TGA: Thermo Gravimetric Analysis; SEM: Scanning Electron Microscopy; XRD: X-Ray Diffraction Analysis; FT-IR: Fourier Transform Infrared Spectroscopy; TLC: Thin-Layer Chromatography; TGA: Thermogravimetric Analysis; PDA: Potato Dextrose Agar

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