Abstract

This work studies the synthesis of a novel Schiff base bis (2- methoxy-1-napthaldehyde) hydrazine hydrate and Schiff based resin poly methylene bis (2- methoxy-1-napthaldehyde) hydrazine hydride via-condensation procedure using with formaldehyde (HCHO) at temperature 70 to 80 °C for 3-4 hours. The synthesized Schiff base BMNHH and resin PMBMNHH were recrystallized from methanol resulting pure compounds. The synthesized compounds were characterized by (CHN), (FT-IR) Thermo Gravimetric Analysis (TGA), EDS analysis and Scanning Electron Microscopy (SEM), Powder X-Ray Diffraction Analysis (XRD). The all results of analytical techniques successfully approved the structure and morphology of newly prepared Schiff base and Schiff based resin. After the characterization the synthesized compounds BMNHH and PMBMNHH was screened against Gram-negative antifungal strains such as, Aspergillus Niger (Gram-negative) Aspergillus flavus (Gram-negative), Candida albicans (Gram-negative) through Agar well diffusion method. The found results conveyed that the tested compounds indicated good sensitivity and enhanced activity against Gram-negative antifungal strains [1,2].

Keywords: Synthesis; Antifungal; Spectroscopy; Condensation; Morphology; Candida albicans

Abbreviations: TGA: Thermo Gravimetric Analysis; SEM: Scanning Electron Microscopy; XRD: X-Ray Diffraction Analysis; FT-IR: Fourier Transform Infrared Spectroscopy; TLC: Thin-Layer Chromatography; TGA: Thermogravimetric Analysis; PDA: Potato Dextrose Agar