Abstract

In DNA homologous recombination repair (HRR) several proteins are encoded by BRCA1 and BRCA2. Any mutation in HRR pathway increases risk of tumor formation as a result of DNA destroying factors like salts of platinum, anthracyclines and novel agents that can damage the DNA homologous repair pathway in the form of inhibitors. Hereditary mutation in BRCA2 gene is linked with germline mutation that contribute to develop breast cancer in women. In current study, phylogenetic analysis of BRCA2 gene in 3 different species is compared to obtain similarities in that gene. Further analysis of gene structure to find exons and introns in these species is done. This proposed study supports the divergence of these 3 species from their common ancestors due to diversity in genes on chromosomes as a result of gene distribution. This current research on BRCA2 gene in humans as compared to other species help us to observe evolutionary changes in that gene through phylogenetic.

Keywords:BRCA2 gene; Germ-line mutations; Gene structures; Phylogenetic analysis