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Research in Medical & Engineering Sciences

Escherichia coli Harboring Mcr-1 on a Novel Plasmid in a Mink in Eastern China

  • Open or CloseXinxing Wang1, Lin Qi2* and Qiaoyun Wang2

    1School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, China

    2Therapeutic Center for Liver Disease, 960th Hospital of PLA, China

    *Corresponding author:Lin Qi, Therapeutic Center for Liver Disease, 960th Hospital of PLA, China

Submission: March 22, 2022;Published: April 01, 2022

DOI: 10.31031/RMES.2022.09.000720

ISSN: 2576-8816
Volume 9 Issue 3


In the current study, we described the characterization of an mcr-1-positive E. coli isolate from a dead mink in Dongping Lake, China. The molecular characterization of plasmids was also investigated. The strain was resistant to colistin, but it remained susceptible to several other agents, including amikacin, piperacillin-tazobactam, all carbapenems, and ESBLs. E. coli Mink_1 belonged to sequence type 140. Whole Genome Sequencing (WGS) showed that two plasmids, pM1mcr and pM1ctx, coexisted in the same bacterial. Blast and phylogenetic tree imply that Epidemic plasmids are vehicles for the dissemination of colistin resistance genes among the Enterobacterales. Restrictive use of antibiotics in animal husbandry should be taken to reduce the dissemination of mcr-1.

Keywords: Mcr-1; Mink; Plasmid; Escherichia coli

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