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A Potential Mechanism for Triggering Cytokine Storm in Covid-19 Patients

Author by: Harald Butterweck And Alfred Weber*

Article Type: Opinion

Published: September, 2020

Journal Name: COJ Biomedical Science & Research

Abstract: Infection with SARS-CoV-2 can result in severe disease characterized by cytokine storm and systemic inflammation. Despite huge efforts, there is only initial evidence that the humoral immune response and particularly the development of antibodies targeting SARS-CoV-2 nucleoprotein could play a decisive role for disease severity. Here, we present the opinion that severe Covid-19 disease could be co-triggered by anti-SARS-Cov-2 nucleoprotein antibodies, which are cross-reactive with human interleukin-11 and inhibit its anti-inflammatory and tissue protective function.

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