Abstract

Topical is the trend of investigation, that connected with synthesis of perspective for medical practice materials on the base of calcium carbonate (CaCO₃, CC). Among a number of polymorphous modifications of calcium carbonates (crystalline anhydrous calcite, aragonite, vaterite; hydrated - mono- (CaCO₃·H₂O) hexahydrate- (CaCO₃·6H₂O); amorphous phase CC) the greatest interest for application as materials for targeted delivery of medical preparations presents vaterite. The results of bio mineralization simulation of calcium carbonate with participation of egg white albumine (ALB) in conditions precipitation from water solutions in water system CaCl₂-Na₂CO₃-ALB-Н2О are considered and carried out assessment effect of ALB content in solution on formation in composition of synthesis products of phases Calcite (C), Aragonite (A) and Vaterite (V) were realized. The synthesis products identified by methods of physical and chemical analysis (chemical, X-Ray, infrared spectral analysis, scanning- and translucent electron microscopy) and fundamental interactions composition - synthesis conditions - structure - properties for prepared synthesis products were estimated. Developed and realized approaches for directed synthesis materials with regulated in course of synthesis and following processing properties on the base of calcium carbonate for medical purposes and variants of applications in medical practice synthesized materials were considered. .

Keywords:Calcium carbonate; Synthesis; Albumin; Bio mineralization; Simulation