The Author ensures that the research has been conducted responsibly and ethically with adherence to all relevant regulations. read more..
Faculty of Pharmaceutical Science, Hokuriku University, Japan
*Corresponding author:Yoshifumi Murata, Faculty of Pharmaceutical Science, Hokuriku University, Japan
Submission: March 15, 2021;Published: March 24, 2021
ISSN : 2576-8840Volume15 Issue1
Film Dosage Forms [FDs] prepared using water-soluble polymers are a strategy for drug delivery to local disease sites. In this study, we prepared FDs incorporating rebamipide as a model drug using various types of sodium alginates [Alg-Nas] as the film base via the casting method. Both the dissolution profile of each FD and the drug dissolution profile from the FD were investigated in a limited amount of physiological saline. A thin film incorporating rebamipide was obtained when either 2-4% low-molecular-weight Alg-Na or 1.5% high-molecular-weight Alg-Na containing chitin were used as the film base. When the FD was brought in contact with the test medium, the film matrix swelled and disintegrated. The disintegration profile of the FD differed according to the type of Alg-Na. However, the disintegration of the FD film matrix did not affect the drug dissolution rate. All materials used for the preparation of the FDs were selected according to their safety for oral administration; therefore, FDs may be an attractive therapeutic form for use in the oral cavity.
Keywords: Sodium alginate; Film dosage form; Rebamipide; Film disintegration profile; Drug release profile
Get access to the full text of this articlePh.D in Agriculture from Faculty of Agriculture, Tohoku University
Research Professor, PhD, Holistic Research Institute
Professor, Chief Doctor, Director of Department of Pediatric Surgery, Associate Director of Department of Surgery, Doctoral Supervisor Tongji hospital, Tongji medical college, Huazhong University of Science and Technology
Senior Research Engineer and Professor, Center for Refining and Petrochemicals, Research Institute, King Fahd University of Petroleum and Minerals (KFUPM), Dhahran, Saudi Arabia
Fellow of International Agency for Standards and Ratings (IASR), Edith Cowan University, Sarich Neuroscience Research Institute
Chancellor Emeritus / Professor Emeritus of Chemistry and Physics, University of Missouri–St. Louis
Ph.D in Science from the Federal University of Alagoas, UFAL, Brazil
Assistant Professor in College of Architecture, Art and Design
Interim Dean, College of Education and Health Sciences, Director of Biomechanics Laboratory, Sport Science Innovation Program, Bridgewater State University
Wenzhou Medical University, China
Fooyin University, Taiwan
Saglik Bilimleri University, Turkey
Vincent Pol University, Poland
National Defence University of Malaysia, Malaysia
Dogus University, Turkey
Hope College, USA
Russian Academy of Sciences, Russia
Southern Cross University, Australia
Umm Al-Qura University, Saudi Arabia
City University of New York, USA
Khalifa University of Science & Technology, United Arab Emirates
Hebei Normal University, China
Alexandria University, Egypt
Indian Institute of Technology Kharagpur, India
Council for Agriculture Research and Analysis of Agri Economy (CREA), Italy
King Fahd University of Petroleum and Minerals, Saudi Arabia
King Abdulaziz University, Saudi Arabia
University of Oregon, USA
University of Edinburgh, Scotland
University of Tennessee, USA
Central University of Venezuela, Venezuela
Islamic Azad University Central Tehran Branch, Iran
Tourin University, Italy
Teaching & Public Speaking, Spain
Paeditric Hospital "Giovanni XXIII", Italy
University of Nicosia, Cyprus
Universidad Miguel Hernández de Elche, Spain
Oral Roberts University, USA
Beijing Normal University, China
Howard University, USA
Edith Cowan University, Australia
Dubai Health Authority, UAE
University of Minnesota, USA
Indian Institute of Technology Kharagpur, India
Serhal Hospital, Lebanon
University of Malta, Malta
National Center for Global Health and Medicine, Japan
Molloy College, USA
Federal University of Piauí, Brazil
Krankenhaus Nordwest Hospital, Germany
Laval University, Canada
Cinvestav-Unidad Saltillo, Mexico
UPMC Hamot Neuroscience Institute, USA
Ramon Llull University, Spain
White Bear Associates, LLC, USA
Lehigh University, USA
California Southern University, USA
Institute of Solid State Physics of RAS, Russia
University of Buenos Aires, Argentina
Mansoura University, Egypt
King Saud University, Saudi Arabia
University of Coimbra, Portugal