Abstract

Therapeutic proteins have emerged with a significant role in the treatment of a broad spectrum of diseases, including metabolic disorders, autoimmune diseases, and bone regeneration. However, the efficacy of therapeutic proteins is limited by their immunogenicity, instability and short half-life. Nowadays, the use of therapies such as bone morphogenetic proteins (BMP) is limited by the inefficient delivery. The high doses applied are frequently related to adverse and severe effects. Aiming to overcome these limitations, the use of polymers as matrixes provide several strategies for the application of therapeutic proteins in organisms. This work presents the main used polymers besides collects some essential aspects related to therapeutic proteins used in bone regeneration.