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Research & Development in Material Science

Protein Release Systems for Bone Regeneration

  • Open or Close Diana Daniel Pérez and Fernando Gomes de Souza Junior*

    Institute of Macromolecules, Federal University of Rio de Janeiro, Brazil

    *Corresponding author: Fernando Gomes de Souza Junior, Institute of Macromolecules, Professor Eloisa Mano, Federal University of Rio de Janeiro, Technology Center-University City, Av Horacio Macedo-2030, Brazil

Submission: March 07, 2018;Published: May 08, 2018

DOI: 10.31031/RDMS.2018.05.000625

ISSN: 2576-8840
Volume5 Issue5


Therapeutic proteins have emerged with a significant role in the treatment of a broad spectrum of diseases, including metabolic disorders, autoimmune diseases, and bone regeneration. However, the efficacy of therapeutic proteins is limited by their immunogenicity, instability and short half-life. Nowadays, the use of therapies such as bone morphogenetic proteins (BMP) is limited by the inefficient delivery. The high doses applied are frequently related to adverse and severe effects. Aiming to overcome these limitations, the use of polymers as matrixes provide several strategies for the application of therapeutic proteins in organisms. This work presents the main used polymers besides collects some essential aspects related to therapeutic proteins used in bone regeneration.

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