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1Department of Neurology and Epileptology, Eberhard Karl University of Tübingen, Germany
2Department for Orthopaedics and Traumatology, ATOS Clinic Heidelberg, Germany
3Department of Pathology Klinikum Kassel, Germany
*Corresponding author:Katharina Kneer, Department of Neurology and Epileptology, Eberhard Karl University of Tübingen, Germany
Submission: April 10, 2023; Published: May 09, 2023
Volume2 Issue1 May , 2023
Background: Osteochondral Lesions (OCL) occur due to repeated traumatic injury to bone and cartilage,
triggering pathological changes of subchondral bone. Treatment effects are very variable and often poorly
predictable. To date, there is no histopathological classification available.
Methods: A total of 76 cases with OCL of the ankle (64% male, 26±13 years) were included in the study
and investigated by conventional microscopy and immunohistochemistry (CD56, CD68, CD31).
Result: Four histological types of OCL were identified: Type I aseptic osteonecrosis, Type II Granulation
tissue with neovascularization and moderate inflammatory reaction, Type III Bone regeneration, Type IV
Degenerative changes.
Conclusion: OCL structures are inhomogeneous. We assume that Type I appears as an initial phase of OCL
and can turn into Types II, III or IV, whereas II and III can be seen as a continuous process, Type IV is most
likely not pathologically linked to subtypes II and III. We assume that the type affecting the can influence
the course of healing and treatment outcome and should be considered regarding therapy choice and
initiation. We suggest a pathological investigations following arthroscopy biopsies to investigate and
classify the destruction of cartilage allowing aa evaluation and improvement of treatment success.
Keywords:Osteochondral lesion; Ankle; Classification
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