Abstract

Hemorheological indexes, living habits, medical history and genetics factor are primary risk factors in Coronary Heart Disease (CHD). In the present study the relation of all factors to the severity of CHD was examined. The data of 282 patients (mean age: 60±9 years) diagnosed with CHD and 229 healthy controls (mean age: 59±7 years) from Wenzhou Medical University were analyzed. All detected hemorheological indexes (except for total bilirubin, fasting blood, uric acid and triglyceride) were determined associated with CHD (P< 0.01). The factors of smoking, hypertension, diabetes and gout reached statistical significant level (P< 0.05) in logistic regression analyses with CHD and four events reveal more than 99% accuracy for CHD prediction. The ten selected SNPs have not found closely related to CHD in Wenzhou people, but found that rs3782886, rs671, 4977574 and rs2383206, four SNPs locus can affect the uric acid content and rs1842896 can affect the LDL-CH concentration in blood and thus indirectly contribute to the incidence of CHD. These results indicate that these detected hemorheological indexes, living habits, medical history and genetics factor may have the possibility as an adjunct to early warning of CHD.

Keywords: Coronary heart disease; Hemorheological indexes; Living habits; Medical history; SNP

Abreviations: ALT: Alanine Transaminase; AST: Aspertate Amino Transferase; FBG: Fasting Blood-Glucose; SCr: Serum Creatinine; UA: Uric Acid; T-CH: Total Cholesterol; HDL-CH: High Density Lipoprotein Cholesterol; LDL-CH: Low Density Lipoprotein Cholesterol; WBC: White Blood Cell; Hb: Hemoglobin; PLT: Blood Platelet; HVR4: Hypervariable Region 4; EDTA: Ethylene Di Amine Tetra Acetic Acid