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Abstract

Novel Approaches in Cancer Study

Steric Influence on Anti-Cancer Activity of Phenyl Acridine Derivatives

  • Open or CloseAbhilash Thakur1, Mamta Thakur2*, Neelu Malviya3 and Brij Kishor Tiwari4

    1Oxford International Institute, Shantanu Education Society, Indore, India

    2Department of Applied Sciences, Symbiosis University of Applied Sciences, Indore, India

    3Department of Chemistry, Maharani Laxmibai P.G. College, Indore, India

    4Department of Chemistry, G.L. Bajaj Institute of Technology and Management, Greater Noida, India

    *Corresponding author:Mamta Thakur, Department of Applied Sciences, Symbiosis University of Applied Sciences, Indore, India

Submission: June 01, 2020 Published: August 18, 2020

DOI: 10.31031/NACS.2020.05.000604

ISSN:2637-773X
Volume5 Issue1

Abstract

Present study represents the steric influence on the anti-cancer activity (DNA binding affinity) for the set of 27 Phenyl acridine derivatives. Quantitative structure activity methodology has been adopted to understand the steric influence on the DNA binding affinity of the compounds. Preliminary step of the method is the generation of structural, topological and physicochemical parameters. Relationship between these structural features and DNA binding affinity (logK) has been developed using multiple linear regression analysis.From the study it is observed that the parameters representing steric and volumetric parameters of the molecule are playing dominating role over the other parameters in characterization of the DNA binding of phenyl acridine derivatives as an anti-canceragent. Statistical analysis exhibits the dominance of approximate surface area and surface tension with hydrophobicity and polarizability factors in modeling of DNA binding affinity. QSAR models developed in present study are cross validated by variety of cross validation parameters. The model obtained in the study is useful to model a novel derivative in the series of Phenyl acridines.

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