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1School of Liberal Studies and Education, Navrachana University, India
2Sun Pharma Advance Research Center, India
3Department of Applied Chemistry, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, India
4Department of Energy Engineering, Republic of Korea
5Greenhouse Gas Center, Korea Institute of Energy Research, Republic of Korea
6School of Science, GSFC University, India
*Corresponding author:Pankaj Sharma, Department of Applied Chemistry, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara-390 001, Gujarat, India
Submission: November 25, 2022; Published: January 06, 2023
Volume2 Issue3December , 2023
Theobromine (3,7-dimethylpurine-2,6-dione), is used as vasodilator, a blood vessel widener), bronchodilator, as an aid in urination and as a heart stimulant, asthma and cough. Therefore, it is important to evaluate the biocompatibility of theobromine to ensure the safety of people consuming it. Furthermore, a quick and easy method has been optimized and validated to determine the quantity of heavy metals like V, Co, Ni, Cd, Hg, Pb and As, present in commercial theobromine by using quadrupole inductively coupled plasma mass spectrometry (Q-ICP-MS). The detection limits were between 0.16 and 7.23μg/L and quantification limits were between 1.5 and 60μg/L. The mean recoveries±standard deviations were varied between 83.1±0.5% and 106.7±2.1% and the coefficients of variation were between 0.2% and 3.1%. The method precision, in terms of relative standard deviation, was below 2.23%. The method uncertainty expressed as expanded uncertainty was found to be≤3.6%..
Keywords:Theobromine; Elemental impurities; Class 1 and 2A; Q-ICP-MS; Analytical method validation; Concurrent analysisz
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