Abstract

defects. This study aims to characterize newborns with congenital defects at birth, evaluating the association with pre- and perinatal factors in comparison with newborns without these defects. A retrospective descriptive epidemiological study based on data from the Information System on Live Births between 2008 and 2018. In the period, 32,124,447 live births were reported in Brazil; of this total, 225,561 had congenital defects identified at birth. The detection of these anomalies was significantly more frequent among the maternal age group from 45-49 years old; mothers with ≥12 years of schooling; legally separated mothers; mothers who had -3 prenatal visits; premature pregnancies of 28-31 weeks; triplet pregnancies or more; women who underwent cesarean delivery; yellow color; male sex; newborns with a 5’ Apgar score 0-2 and with very low birth weight (P<0.0001). The results of this study suggest a progressive increase of congenital defects cases in the country over the years, although it still points out possible underdiagnosis and underreporting, highlighting the need for interventions for adequate and early recognition of congenital defects.

Keywords: Congenital defects; Infant; Public health; Brazil; Perinatal care

Keywords:CD: Congenital defects; SINASC: Sistema de Informações sobre Nascidos Vivos; DATASUS: Departamento de Informática do Sistema Único de Saúde, CEP-CONEP: Research Ethics Committees-National Research Ethics Commission; DNV: Declaration of Live Births; ICD-10: International Classification of Diseases; ECLAMC: The Latin American Collaborative Study of Congenital Malformations; OCD: Osteo Condro Displasias; SIAT: National System of Information on Teratogenic Agents; ICBDSR: International Clearinghouse for Birth Defects Surveillance and Research; EUROCAT: European Registration of Congenital Anomalies and Twins; BINOCAR: British and Irish Network of Congenital Anomaly Researchers; RD: Rare Diseases