Abstract

In the worldwide, approximately 20 to 50% of populations suffer from periodontal diseases [1]. According to NHIS (2017), 7.38 million people experienced medical treatment because of periodontitis in 2009 and 14.19 million people in 2016 in South Korea, which was increased by 92.3% in only 5 years [2]. The major oral pathogenic bacteria that occur periodontitis are Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum by disruption of alveolar bone and inflammation disperse [3,4]. Periodontitis is well-known for a risk of many other diseases such as cardiovascular disease, type 2 diabetes, non-alcoholic fatty liver, and rheumatic arthritis [1,5]. It is important that a treatment of periodontitis can protect various diseases, and thus, prevention of oral pathogens is necessary.