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Approaches in Poultry, Dairy & Veterinary Sciences

Probiotics to Control Oral Microbiome, Resulting in Gut Microbiome

Yukyung Choi1,2 Soomin Lee2, Yohan Yoon 1,2 and Heeyoung Lee2*

1 Department of Food and Nutrition, Women’s University, Korea

2 Risk Analysis Research Center, Women’s University, Korea

*Corresponding author: Heeyoung Lee, Risk Analysis Research Center, Women’s University, Seoul04310, Korea

Submission: May 30, 2018; Published: June 15, 2018

DOI: 10.31031/APDV.2018.04.000578

ISSN: 2576-9162
Volume4 Issue1


In the worldwide, approximately 20 to 50% of populations suffer from periodontal diseases [1]. According to NHIS (2017), 7.38 million people experienced medical treatment because of periodontitis in 2009 and 14.19 million people in 2016 in South Korea, which was increased by 92.3% in only 5 years [2]. The major oral pathogenic bacteria that occur periodontitis are Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum by disruption of alveolar bone and inflammation disperse [3,4]. Periodontitis is well-known for a risk of many other diseases such as cardiovascular disease, type 2 diabetes, non-alcoholic fatty liver, and rheumatic arthritis [1,5]. It is important that a treatment of periodontitis can protect various diseases, and thus, prevention of oral pathogens is necessary.

The treatment of periodontal diseases is based on removing bacterial plaque and preventing bacterial growth, and several drugs such as ascorbic acid, antibacterials, antibiotics and etc. have been used for the treatment. However, ascorbic acid has little therapeutic effect, and antibacterials and antibiotics have a limitation for a fundamental treatment of periodontal diseases. Tetracycline and metronidazole have been primarily used for periodontal disease, but the antibiotics can occur side effects such as the emergence of stomach disorder, recolonization of the pathogens, and antibioticresistant [6]. Therefore, the fundamental therapy to decrease oral pathogens in oral microbiome is important. For these reasons, a new therapy using probiotics which can prevent oral pathogens should be suggested.

According to FAO-WHO (2002), probiotics are live microorganisms that are effective on health when people consume adequate volume [7]. Probiotics markets in the world will grow, and some professionals predict the value for that markets exceed 60 trillion in 2020 [8]. Probiotics regulate immunity in host [9,10], and some researchers found that the probiotics decrease the inflammatory cytokines or induces another regulatory system, and thus, symptom of disease was relieved in the mouse model [11-13].

Lactobacillus is one of the major probiotics that decreased growth of P. gingivalis and P. intermedia by 82% and 65%, respectively[14], and Lactobacillusreuteri can decrease bleeding and inflammation of gums [15,16]. Also, sterilized gauze inoculated with probiotics has antibacterial effects on oral pathogens such as Bacteroides, Actinomyces, Streptococcus intermedius, and Candida albicans [17]. Through some researches, probiotics that have antibacterial effects can be used for the treatment of periodontitis, and furthermore, it can be useful for improvement of oral microbiome.

Previously, probiotics are generally used to improve gut health. However, it was hypothesized that oral microbiome changed by probiotics may affect gut microbiome [18,19]. The compositions of oral microbiome between the healthy group and periodontitis patients were different. In healthy group, Neisseria lactamica consisted 8.8% in oral microbiome, but the periodontitis patients had 24.5%. Regarding Streptococcus sanguinis, causing inflammation in gum, healthy group had 2.9% composition, but the patients had 13.5% composition [20]. When P. gingivaliswas oralgavaged in the mouse model, the gut microbiome composition of Firmicutes and Bacteroidetes was changed from 55.4% and 38.7% to 72.8% and 17%, respectively [21]. Oral microbiome change caused even allergy response such as atopic dermatitis because gut microbiome was influenced and immunity system was unbalanced [22,23].

In conclusion, future studies to evaluate the correlation between oral and gut microbiome, are necessary, and thus, studies to develop to control oral microbiome, resulting in improved gut microbiome need to be conducted.


  1. Nazir MA (2017) Prevalence of periodontal disease, its association with systemic diseases and prevention. Int J Health Sci (Qassim) 11(2): 72-80.
  2. NHIS (National Health Insurance Service) (2017) 2016 National Health Insurance Statistical Yearbook
  3. Chaves ES, Jeffcoat MK, Ryerson CC, Snyder B (2000) Persistent bacterial colonization of Porphyromonas gingivalis, Prevotella intermedia, and Actinobacillusactinomycetemcomitans in periodontitis and its association with alveolar bone loss after 6 months of therapy. J Clin Periodontol 27(12): 897-903.
  4. Yang NY, Zhang Q, Li JL, Yang SH, Shi Q (2014) Progression of periodontal inflammation in adolescents is associated with increased number of Porphyromonas gingivalis, Prevotella intermedia, Tannerellaforsythensis and Fusobacterium nucleatum. Int J Paediatr Dent 24(3): 226-233.
  5. Han P, Sun D, Yang J (2016) Interaction between periodontitis and liver diseases. Biomed Rep 5(3): 267-276.
  6. Addy M (1994) Local delivery of antimicrobial agents to the oral cavity. Adv Drug Deliv Rev 13(1-2): 123-134.
  7. FAO-WHO (2002) Guidelines for the evaluation of probiotics in food. London, Ontario, Canada, pp. 1-11.
  8. Grand view research (2016) Probiotics market size estimated to reach $52.34 billion by 2020. San Francisco, California, USA.
  9. Drago L, Toscano M, Pigatto PD (2013) Probiotics: Immunomodulatory properties in allergy and eczema. G Ital Dermatol Venereol 148(5): 505- 514.
  10. Niccoli AA, Artesi AL, Candio F, Ceccarelli S, Cozzali R, et al. (2014) Preliminary results on clinical effects of probiotic Lactobacillus salivarius LS01 in children affected by atopic dermatitis. J Clin Gastroenterol 48(Suppl 1): S34-36.
  11. Yeung CY, Chan WT, Jiang CB, Cheng ML, Liu CY, et al. (2015) Amelioration of chemotherapy-induced intestinal mucositis by orally administered probiotics in a mouse model. PLoS One 10(9): e0138746.
  12. Bellavia M, Rappa F, Lo Bello M, Brecchia G, Tomasello G, et al. (2014) Lactobacillus casei and bifidobacterium lactis supplementation reduces tissue damage of intestinal mucosa and liver after 2,4,6-trinitrobenzenesulfonic acid treatment in mice. J Biol Requl Homeost Agents 28(2): 251-261.
  13. Geier MS, Butler RN, Giffard PM, Howarth GS (2007) Lactobacillus fermentum BR11, a potential new probiotic, alleviates symptoms of colitis induced by dextran sulfate sodium (DSS) in rats. Int J Food Microbiol 114(3): 267-274.
  14. Koll-Klais P, Mandar R, Leibur E, Marcotte H, Hammarstrom L, et al. (2005) Oral lactobacilli in chronic periodontitis and periodontal health: species composition and antimicrobial activity. Oral Microbiol Immunol 20(6): 354-361.
  15. Vivekananda MR, Vandana KL, Bhat KG (2010) Effect of the probiotic Lactobacilli reuteri (Prodentis) in the management of periodontal disease: a preliminary randomized clinical trial. J Oral Microbiol 2:10.
  16. Vicario M, Snatos A, Violant D, Nart J, Giner L (2013) Clinical changes in periodontal subjects with the probiotic Lactobacillus reuteriprodentis: a preliminary randomized clinical trial. Acta Odontol Scand 71(3-4): 813- 819.
  17. Koll P, Mandar R, Marcotte H, Leibur E, Mikelsaar M, et al. (2008) Characterization of oral lactobacilli as potential probiotics for oral health. Oral Microbiol Immunol 23(2): 139-147.
  18. Kodukula K, Faller DV, Harpp DN, Kanara I, Pemokas J, et al. (2017) Gut microbiota and salivary diagnostics: the mouth is salivating to tell us something. Biores Open Access 6(1): 123-132.
  19. Gomez A, Espinoza JL, Harkins DM, Leong P, Saffery R, et al. (2017) Host genetic control of the oral microbiome in health and disease. Cell Host Microbe 22(3): 269-278.
  20. Choi EG (2015) Analysis of oral microbes in healthy subjects and periodontitis patients. Theis is of master of science in Yonsei University.
  21. Arimatsu K, Yamada H, Miyazawa H, Minagawa T, Nakajima M, et al. (2014) Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota. Sci Rep 4: 4828.
  22. Gemmell E, Seymour GJ (2004) Immunoregulatory control of Th1/Th2 cytokine profiles in periodontal disease. Periodontol 35: 21-41.
  23. Fujimura KE, Lynch SV (2015) Microbiota in allergy and asthma and the emerging relationship with the gut microbiome. Cell Host Microbe17(5): 592-602.

© 2018 Heeyoung Lee. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and build upon your work non-commercially.