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The Influence of Various Drags on Mortality of Mice and the Concentration of Proinflammatory Cytokines in Blood at Sepsis Caused by E. Coli

  • Open or Close Zabrodskii PF*

    Saratov Medical University “REAVIZ”, Saratov, Russian Federation

    *Corresponding author: PF Zabrodskii, Saratov Medical University “REAVIZ”, Saratov, Russian Federation, Russia

Submission: March 22, 2018; Published: May 18, 2018

DOI: 10.31031/AICS.2018.01.000512

ISSN 2639-0531
Volume1 Issue3


Experiments on albino mice showed that administration m-cholinomimetic (aceclydine), n-cholinomimetic (nicotine), reversible inhibitor of acetylcholinesterase (neostigmine methyl sulfate), n-cholinomimetic α7nAChRs agonist (GTS-21), epinephrine hydrochloride, adenomimetic β2ARs agonist (hexaprenaline sulfate) causes decrease in mice mortality in sepsis caused by the administration (i.p.) of E. coli O157:H7 and the concentration of TNF-α, IL-1β and IL-6 in the blood in comparison with parameters at sepsis without use of drugs.

Keywords: Sepsis; Cytokines; E. coli; Cholinergic drugs; Adrenergic drugs

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