Abstract

This work is devoted to scientific research carried out to investigate the content of cranberry fruits (Vaccinium macrocarpon L., Ericaceae). To evaluate the influence of composition on anti-inflammatory activity, cranberry fruits were collected from eight Serbia growing regions. Eight extracts from these fruits were prepared. Extracts were analyzed for phytochemical composition and evaluated for their anti-inflammatory effects in human monocytes (THP-1 cells). All were able to reduce Lipopolysaccharide (LPS) -induced production of pro-inflammatory cytokine interleukin 6 (IL-6) at 50μg/mL, with inhibition ranging between 10.09-42.7%. The research results show phytochemicals present in varying quantities in cranberry fruits a role in the anti-inflammatory effects of cranberry extracts on human monocytes.

Keywords:Cranberry; Anti-inflammatory; Antioxidant; Cytokines; Polyphenols; Phytochemicals; Monocytes