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Advances in Complementary & Alternative medicine

Diversity of Phytochemical Composition of the Content of Cranberry Fruits (Vaccinium Macrocarpon L., Ericaceae) Depending on Growing Regions

  • Open or CloseDušica P Ilić*

    University of Niš, Faculty of Electronic Engineering, Serbia

    *Corresponding author: Dušica P Ilić, University of Niš, Faculty of Electronic Engineering, Aleksandra Medvedeva 14, 18115 Niš, Serbia

Submission: May 25, 2022; Published: June 29, 2022

DOI: 10.31031/ACAM.2022.07.000657

ISSN: 2637-7802
Volume7 Issue2


This work is devoted to scientific research carried out to investigate the content of cranberry fruits (Vaccinium macrocarpon L., Ericaceae). To evaluate the influence of composition on anti-inflammatory activity, cranberry fruits were collected from eight Serbia growing regions. Eight extracts from these fruits were prepared. Extracts were analyzed for phytochemical composition and evaluated for their anti-inflammatory effects in human monocytes (THP-1 cells). All were able to reduce Lipopolysaccharide (LPS) -induced production of pro-inflammatory cytokine interleukin 6 (IL-6) at 50μg/mL, with inhibition ranging between 10.09-42.7%. The research results show phytochemicals present in varying quantities in cranberry fruits a role in the anti-inflammatory effects of cranberry extracts on human monocytes.

Keywords:Cranberry; Anti-inflammatory; Antioxidant; Cytokines; Polyphenols; Phytochemicals; Monocytes

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