1Jiwaji University, India
2Department of Biosciences, Manipal University Jaipur, India
3Department of Medical Biotechnology, Yeungnam University, South Korea
*Corresponding author: GBKS Prasad, Centre for Translational Research, School of Studies in Biochemistry, Jiwaji University, Gwalior-474011, India
Submission: April 03, 2018; Published: April 25, 2018
ISSN: 2637-7802Volume2 Issue3
Objectives:The present study investigated antihyperglycemic, and antioxidant potentials of Eugenia jambolana seed in streptozotocin (STZ)- induced diabetic rats.
Methods:Male Wistar rats were made diabetic by a single dose of Streptozotocin (45mg/kg body weight .i.p). The animals were administered of ethanolic extract of Eugenia jambolana (E. jambolana) seed at the dose of (250mg/kg body weight) orally. The therapeutic functions of the E. jambolana was assessed by monitoring, Blood glucose levels and body weight of rats were measured at weekly intervals and glycosylated hemoglobin, lipid profile and biomarkers of oxidative stress, liver and kidney function markers and degree of DNA damage were also measured at the end of the study.
Result:Daily administration of E. jambolana seed extract for 28 days resulted in significant reductions of blood glucose and glycosylated hemoglobin levels. There was also a significant increase in HDL-Cholesterol levels with concomitant decreases in total cholesterol, triglycerides, LDL-Cholesterol, VLDL. Also, a significant improvement in enzymatic and non-enzymatic biochemical markers of oxidative stress. The kidney and liver functions were also reverted back to near normalcy by E. jambolana ethanolic seed extract.
Conclusion:The present results showed the anti-hyperglycemic, and anti-oxidative potential of of ethanolic extract of E. jambolana in STZ induced diabetic rats. It was concluded that the ethanolic extract of E. jambolana is potent in regulating not only hyperglycemia but also hyperlipidemia and oxidative stress in STZ induced diabetic rats.
Keywords:Diabetes mellitus; Eugenia jambolana; Oxidative stress; Blood glucose; Antihyperlipidemic; Antioxidant
Abbreviations:E. jambolana: Eugenia jambolana; BW: Body Weight; GSH: Reduced glutathione; HbA1c: Glycosylated Haemoglobin; GPx: Glutathione Perosidase; GR: Glutathione Reductase; GST: Glutathione-S Transferase; HDL: High-Density Lipoprotein cholesterol; LDL: Low-Density Lipoprotein cholesterol; SOD: Super Oxide Dismutase; AST: Aspartate Transaminase; ALT: Alanine Transaminase; VLDL: Very Low Density Lipoprotein cholesterol; TBARS: Thiobarbituric Acid Reactive Substances