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Abstract

Advances in Complementary & Alternative medicine

Antidiabetic Potential of Eugenia jambolana Ethanolic Seed Extract: Effect on Antihyperlipidemic and Antioxidant in Experimental Streptozotocin-Induced Diabetic Rats

Submission: April 03, 2018; Published: April 25, 2018

DOI: 10.31031/ACAM.2018.02.000540

ISSN: 2637-7802
Volume2 Issue3

Abstract

Objectives:The present study investigated antihyperglycemic, and antioxidant potentials of Eugenia jambolana seed in streptozotocin (STZ)- induced diabetic rats.

Methods:Male Wistar rats were made diabetic by a single dose of Streptozotocin (45mg/kg body weight .i.p). The animals were administered of ethanolic extract of Eugenia jambolana (E. jambolana) seed at the dose of (250mg/kg body weight) orally. The therapeutic functions of the E. jambolana was assessed by monitoring, Blood glucose levels and body weight of rats were measured at weekly intervals and glycosylated hemoglobin, lipid profile and biomarkers of oxidative stress, liver and kidney function markers and degree of DNA damage were also measured at the end of the study.

Result:Daily administration of E. jambolana seed extract for 28 days resulted in significant reductions of blood glucose and glycosylated hemoglobin levels. There was also a significant increase in HDL-Cholesterol levels with concomitant decreases in total cholesterol, triglycerides, LDL-Cholesterol, VLDL. Also, a significant improvement in enzymatic and non-enzymatic biochemical markers of oxidative stress. The kidney and liver functions were also reverted back to near normalcy by E. jambolana ethanolic seed extract.

Conclusion:The present results showed the anti-hyperglycemic, and anti-oxidative potential of of ethanolic extract of E. jambolana in STZ induced diabetic rats. It was concluded that the ethanolic extract of E. jambolana is potent in regulating not only hyperglycemia but also hyperlipidemia and oxidative stress in STZ induced diabetic rats.

Keywords:Diabetes mellitus; Eugenia jambolana; Oxidative stress; Blood glucose; Antihyperlipidemic; Antioxidant

Abbreviations:E. jambolana: Eugenia jambolana; BW: Body Weight; GSH: Reduced glutathione; HbA1c: Glycosylated Haemoglobin; GPx: Glutathione Perosidase; GR: Glutathione Reductase; GST: Glutathione-S Transferase; HDL: High-Density Lipoprotein cholesterol; LDL: Low-Density Lipoprotein cholesterol; SOD: Super Oxide Dismutase; AST: Aspartate Transaminase; ALT: Alanine Transaminase; VLDL: Very Low Density Lipoprotein cholesterol; TBARS: Thiobarbituric Acid Reactive Substances

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