Abstract

Composite lymphoma as an entity was initially described by Custer et al followed by a modified delineation by Hicks et al and Kim et al with a categorical emergence of architecturally diverse and binary cytological subcategories of lymphoma within the same anatomic site or tissue. Composite lymphoma as a disorder essentially describes a biphasic elucidation of an identical malignant clone of cells [1]. A discordant lymphoma may be exemplified by a condition in which two disparate lymphomas may arise at different anatomic locations within an identical time frame (Figure 1). Sequential lymphoma may be characterized by the appearance of two distinctive histological variants of malignant lymphoma detected successively within a similar group of lymph nodes.

Figure 1:CL: small and large B cell zones with cellular pleomorphism [13].