Famitafreshi H and Morteza Karimian*
Department of Physiology, Iran
*Corresponding author: Morteza Karimian, Department of Physiology, Iran
Submission: April 14, 2021;Published: June 08, 2021
Keywords: COVID-19; ARDS; Oxygen; Therapy; ICU
Oxygen therapy is one of the most famous therapies in critically ill patients with different causes . However, high-pressure oxygen therapy is associated with some advantages and disadvantages . This issue may guide the attention to consider this therapy with careful considerations. However, when the situation is critical health care providers may consider these problems insignificant . Maybe, the most important problem and question in this regard are to consider the pros and cons of this therapy in different concepts. At present time every person will consider that oxygen therapy is essential to critically ill patients without considering the side-effects. The most motivation for the presentation of this article is the recent observations in COVID-19 patients and seeing that there is a wide discrepancy among the time of death in individuals that receive oxygen that is in ICU (Intensive Care Unit) . Some of them will die in a short time and some after a long time. So, it can be considered that individuals respond to oxygen differently when other factors will not be considered. ARDS (Acute Respiratory Distress Syndrome) is considered as the end-stage form of COVID-19 infection and usually, oxygen will be considered for these patients at high doses. On the other hand, this therapy has been associated with some serious effects. These serious side-effects will eventually cause considerable damages and compromise lung function. Studies show high-pressure oxygen therapy will cause some substructures damages that eventually will negatively influence oxygen therapy. They have included the emergence of adhesion molecules, recruitment of neutrophil, macrophage dysfunction, and production of chemotactic proteins [5,6]. Also, the production of oxygen-free radicals is one of the most serious side-effects . Although some treatments have been considered for the alleviation of the case such as administration of interleukin receptor blockers  but oxygen, in any case, should be administered. Recent studies suggest the application of conservative therapy is advisable, however more studies are recommended for helping health care to implement more precise oxygen therapy. This is important in critically ill COVID-19 patients because high-pressure oxygen may be the only effective therapy for end-stage patience but the important issue, in this case, is considering that avoiding early high-pressure oxygen in the early stages of therapy seems reasonable. Keeping in mind that many COVID-19 patients, even hours before death are highly oriented, and the respiration is not deeply compromised and unfortunately all of them are highly ventilated. High ventilation may negatively predispose patients to develop more rapidly ARDS. So, considering the above facts, the application of highly controlled oxygen may be more helpful in patients, and high-pressure oxygen therapy may negatively more rapidly compromise lung function.
© 2021 Morteza Karimian. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and build upon your work non-commercially.