Abstract

Objectives: Investigation of effects of seizures and used antiepileptic drugs on serum Paraoxons 1 (PON1) and aryl esterase (PONAryl) activities in patients diagnosed with epilepsy and simple febrile convulsion was aimed.

Materials and methods: Of the patients who were being followed-up with diagnosis of epilepsy and admitted to emergency department with complaint of seizure; patients using sodium valproate, levetiracetam and diagnosed with simple febrile convulsion were included in the study. In order to measure levels of PON1 and PONAryl, venous blood samples were obtained.

Results: When serum PON1 and PONAryl levels of the groups were compared, PON1 and PONAryl levels were determined to be statistically significantly lower in the epilepsy group using sodium valproate (p=0.001, p=0.001).

Conclusion: Valproate had a potent inhibition effect and levetiracetam had weak inhibition effect on PON1 and PONAryl activities. Results suggest need for close follow-up of these patients with impaired oxidative balance due to increased risk of atherosclerosis.

Keywords: Paraoxonase; Arylesterase; Antiepileptic drugs; Epilepsy; Febrile convulsion