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Techniques in Neurosurgery & Neurology

Meningial and Skull Base Metastasis of Glioblastoma: Case Report and Review of the Literature

Submission: January 21, 2018; Published: February 23, 2018

DOI: 10.31031/TNN.2018.01.000510

ISSN 2637-7748
Volume1 Issue2


Glioblastoma is the most aggressive glial tumor of the central nervous system in adults. It’s growth has always been described as a local invasion and it’s direct extension through the dura mater to the skull base is a rare phenomenon. In this paper, we report the unusual case of a 52-year-old patient with disorder language in whom a left temporal lesion was detected on cerebral magnetic resonance imaging (MRI). He underwent a microsurgical resection and the histological examination of the biopsy sample revealed the diagnosis of glioblastoma. Ten months after surgery and concurrent radiochemotherapy, the patient showed visual field degradation and hypoesthesia of the left hemiface. MRI showed contrast-enhanced in the skull base with an extension to the spheno-ethmoidal recess requiring an endoscopic endonasal biopsy which histological examination revealed recurrence of glioblastoma. A targeted therapy was initiated and MRI showed a clear regression of the process at the skull. This report examines the glioblastoma metastases mechanisms outside the central nervous system and the value of targeted therapy in the prognosis of these lesions.

Keywords: Glioblastoma; Metastasis meningial; Skull base

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