Abstract

Background: Ageing is an opening for the initiation of various disorders in an individual’s lifespan. It brings degenerative changes in cellular levels which affects fecundity and longevity.
Aim: Here, we reviewed the upcoming advances in metabolomics and proteomics to identify the metabolite and protein network signalling pathways. Along with, the role of various plants metabolites was also reviewed to understand the mechanism behind the anti-ageing activity. Methods: Clinical studies on ageing provide insight to understand the causative agents through analysing various genetic pathways along with proteomics and metabolomics. In that context, identification of potent biomarkers is required to predict biological as well as chronological age.
Results: In plants, various reports suggest their capability of reversal of degenerative glitches in various signalling pathway. As their metabolites show significant property to cope up with environmental changes along with evolution in specific signalling pathways.
Conclusion: In this review, we can say that plants provide a multitude of bioactive compounds with CNS activity. Along with, the network analyses of ageing or age-related disorders employing proteomics and metabolomics proved to be powerful tool for understanding the core biological processes which influences variations in these abnormalities hindering the longevity of an individual.

Keywords: Anti-ageing; Biomarkers; Proteomics; Metabolomics; Alkaloids; Diterpenes; Phytochemical

Abbreviations:UV: Ultraviolet; 1,5-AG: 1,5-Anhydroglucitol; NAD+: Nicotinamide Adenine Dinucleotide; NADP+: Nicotinamide Adenine Dinucleotide Phosphate; UDP: Acetylglucosamine- Uridine Diphosphate N-Acetylglucosamine; OA: Opthalamic Acid; GTP: Guanosine Triphosphate; CTP: Cytidine Triphosphate; ADP: Adenosine Diphosphate; IMP: Inosine 5’-Monophosphate; KAT7- p15ink4b: Lysine Acetyl Transferase; CUR: Curcumin; LPO: Lipooxygenase; MDA: Malondialdehyde; NO: Nitric Oxide; AGEs: Advanced Glycation Products; APP: Amyloid Precursor Protein; Aβ- Amyloid Beta; p-mTOR: Phospho-Mammalian Target of Rapamycin; p-NF-B: Phospho-Nuclear Factor-Kappa B; D-Gal-D: Galactaose; GOPO: Drug for Joint Supplement; MMP1: Matrix Metalloproteinase; ROS: Reactive Oxygen Species; GB: Gingko Biloba