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Significances of Bioengineering & Biosciences

A Leap towards 3D in Biomedicine: Do We Know How to Deal With it?

  • Open or CloseBahaa Daou1, Julian Zayas-Arrabal1, Nerea Pascual2, Alessandro Silvestri1* and Nuria Alegret1,2*

    1Carbon Bionanotechnology Group, Center for Cooperative Research in Biomaterials (CIC Bioma GUNE), Basque Research and Technology Alliance (BRTA), Donostia-San Sebastián, 20014, Spain

    2Group of Neuromuscular Diseases, Biodonostia Health Research Institute (HRI), Paseo Dr. Begiristain, s/n, 20014 San Sebastián, 20014, Spain

    *Corresponding author: Alessandro Silvestri and Nuria Alegret, Carbon Nanobiotechnology Group, CIC bioma GUNE, Paseo de Miramón 182, 2014 Donostia-San Sebastián, and Group of Neuromuscular Diseases, IIS Biodonostia, Paseo Dr. Begiristain s/n, 20014 San Sebastian, Spain

Submission: August 25, 2021;Published: September 24, 2021

DOI: 10.31031/SBB.2021.05.000613

ISSN 2637-8078
Volume 5 Issue 3


Real life is made in three dimensions. Biological studies, however, have been for a long time based on 2D in vitro cultures. In the past decade, scientists have started to realize that 3D cell culturing methods are essential not only because they provide a similar environment to the in vivo tissue, but also because the cellular behavior in 3D better mimics the real biological scenario. Therefore, 3D scaffolds are having tremendous impact in several fields of modern biomedical research. However, even though with the hype this multidisciplinary field is having, there are multiple concerns regarding lack of handling and evaluating protocols that pose an uncertainty. Herein, we present our subjective reflection and our concerns on the matter, including the limitations and challenges we face from our experience working within such a field, aimed at leaving a mark on the consciousness of the 3D community.

Keywords: Biomedical research; Environment; 3D community; 3D cell cultures; Drug testing

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