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Significances of Bioengineering & Biosciences

Effect of an Aqueous Extract of Fenugreek (Trigonella Foenum Graecum) seeds on Hyperglycemia Induced with Alloxan

Submission: November 20, 2020;Published: December 10, 2020

DOI: 10.31031/SBB.2020.04.000584

ISSN 2637-8078
Volume 4 Issue 2



Diabetes mellitus is a metabolic disease that causes high blood sugar. The number of people suffering from the disease worldwide is increasing at an alarming rate. Fenugreek (Trigonella foenum-graecum) is an herb long used in alternative medicine. This herb has many health benefits. These benefits may be due to fenugreek’s role in improving insulin function.


To evaluate antidiabetic effects of Fenugreek seeds extract on Alloxan-induced diabetic mice.


The total of 30 mice (n=10) were grouped randomly into 3 groups as followings: Group I: Normal control (NC), Group II: Diabetic control (DC) and Group III: Treatment Diabetic Group (DT). Mice were injected with subcutaneous injection 180mg/kg body of freshly prepared of Alloxan and Diabetes mellitus confirmed by testing blood glucose, and mice with blood glucose level of ≥200mg/dl were considered as diabetic. Diabetic mice were received 10mg/kg of body weight from fenugreek extract.


All Diabetic mice that received extract showed a significant decrease in blood sugar (P<0.01).


Fenugreek seeds reduce blood sugar levels.

Keywords: Fenugreek; Trigonella foenum graecum; Alloxan; Diabetes

Abbreviations: NC: Normal Control; DC: Diabetic Control; DT: Diabetic Treatment Group

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