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Significances of Bioengineering & Biosciences

Combretum Adenogonium Induce Anticancer and Antioxidant Effects in Prostate Cancer Cell Line

Submission: June 05, 2017; Published: July 18, 2018

DOI: 10.31031/SBB.2018.02.000534

ISSN 2637-8078
Volume2 Issue2


Plants have been used fortreating various diseases of human beings and animalssince time immemorial. They maintain the health andvitality of individuals, and also cure diseases, includingcancer without causing toxicity. This work investigated the anticancer, antioxidant activities of C. adenogonium roots, leaves, and stems commonly used as anti inflammatory and anti tumor. All the plant parts were extracted using 80% methanol, the anticancer activity was examined by using MTT assay against PC3 (Prostate Cancer) and determine their antioxidant activities by testing Effect ofPlant Methanol Extracts on suppressing whole blood Phagocytes and ROS Production and Metal chelating activities, filter and kept in dark, prepared freshly. The extract C. adenogonium roots, DC has shown very high activity against PC3 (Prostate Cancer) IC50 values 24μg/ml. The extract C. adenogonium leaves, and stems has shown none active anti against PC3 (Prostate Cancer) IC50 values >100, and >100μg/ml respectively. All the extracts Effect ofPlant Methanol Extracts on suppressing whole blood Phagocytes and ROS Production has shown none active in all plants parts under study C. adenogonium roots, leaves, and stems IC50 values>200 . All the examined plant methanol extracts showed different levels of inhibition % for their metal chelating activity at concentration 50μg/mL. C. adenogonium stem 50.87μg/m, C. adenogonium leaves 49.85μg/m,C. adenogonium roots 25.99μg/m.

Keywords: PC3; Chemiluminescenc; Anticancer; Medicinal plants

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