*Corresponding author: Christos Beretas, Paris, France
Submission: November 22, 2019 Published: January 16, 2020
ISSN: 2576-8816Volume8 Issue4
Objective: Pump size exterior artificial pancreas that will keep the glucose between 120-150mg/dl.
Method: The whole project based in idea that we should already know one insulin unit how much is able to go down the glucose and one glucagon’s unit how much is able to increase the glucose. Less than 120mg/dl it uses glucagon’s. More than 150mg/dl it uses insulin. The pump checks the glucose automatically every 8 minutes. The pump (which is software decision) will choose between insulin or glucagon’s base in internal database table with prerequisite glucose values and the insulin or glucagon’s units requiring for each glucose value (adaptive database table for each diabetic). The pump (the software) is able to choose how many insulin or glucagon’s units it should use (that is not based on what the diabetic will eat, but base on the current glucose level that received from the sensor which is located in human body, needle and sensor are one piece). The insulin should have work duration 8 minutes and works instantly.
Result: I chose 120mg/dl as the lowest allowance glucose level because this glucose level is secure for the diabetic (there is a time to prevent big hypoglycemia).
Conclusion: This project offers to diabetic’s insulin injections freedom, hypoglycemia prevention, run emergency tests, ideally for all ages, endocrinologists will have the software to adapt the internal database table of the pump for each diabetic needs.
The pump size exterior artificial pancreas (Figure 1), uses one sensor (the sensor is one material which include the needle that require to inject to human body both glucagon’s or insulin, when the sensor is replacing, replace the needle too, is one device with two operations) to collect the current glucose levels from the human body, when the sensor collect the current glucose level, send the data to the artificial pancreas through a cable, then the artificial pancreas read the received glucose value and through table with prerequisites insulin and glucagon’s units for each received glucose value decide how many insulin units require to decrease the glucose or how many glucagon’s units require to increase the glucose to prevent hypoglycemia. My logic is below 120mg/dl to use glucagon’s and above 150mg/dl use insulin (I chose 120 as the lower level for safety purposes, because the artificial pancreas has the time to increase the glucose in next 8 minutes that will check automatically the glucose and if the glucose goes down will automatically increase it without the diabetic to feel hypoglycemia, I think glucose need some time goes down from 120mg/dl until feeling hypoglycemia, I think there is a time to prevent it). The artificial pancreas is remaining standby when the glucose is between 120-150mg/dl. I set the artificial pancreas to make auto glucose tests every 8 minutes, while I added “emergency test” button which the artificial pancreas is able to do current glucose test and chose either glucagon’s or insulin, this button is useful for hypoglycemia or hyperglycemias cases.
There are two important points, the first one is the insulin, the pump automatically run tests every 8 minutes, thus we can’t use insulin that have a duration one, three, or six hours, this pump needs insulin that have duration 8 minutes and it should work immediate (we should know both how much one insulin unit decrease the glucose in mg/dl and how much one glucagon’s unit increase the glucose in mg/dl to make the best table). The second point is the kids with diabetes below of 10 years old require usually less insulin units, this artificial pancreas is not able to determine the age of the people, for example, cannot be use in 10 years old diabetic, because his/her body require less insulin units than a 25 years old or older diabetic. To overcome this limitation, endocrinologists they will have the software to adapt the internal database table of the pump for each diabetic needs including the need that is require for example a 10-year-old kid.
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