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1College of Chemistry and Life Science, Changchun University of Technology, Changchun, Jilin, 130012, P.R. China
2Jilin Provincial Engineering Laboratory for the Complex Utilization of Petro-resources and Biomass, School of Chemical Engineering, Changchun University of Technology, Changchun, Jilin, 130012, P.R. China
*Corresponding author: Long Zhang, Jilin Provincial Engineering Laboratory for the Complex Utilization of Petro-resources and Biomass, School of Chemical Engineering, Changchun University of Technology, 2055 Yanan Street, Changchun, Jilin, China
Submission: March 03, 2023;Published: March 15, 2023
ISSN: 2576-8816Volume10 Issue 2
Heparin is a natural anticoagulant from animal organs with excellent anticoagulant activity, and it is of high price as the raw material for the preparation of heparin originates from the special organs of animals. There is also the problem of biological rejection. As Pentosan sulfate has a similar chemical structure to heparin and is prepared from renewable plant-derived pentosan, so the preparation and biological activity evaluation of pentosan sulfate has become a new research hotspot in the field. This paper mainly reviews the structure, physical and chemical properties, preparation methods and the analysis and evaluation of various biological activities of pentosan sulfate. The future development of pentosan sulfate is to find plant-based pentosans with similar structure to heparin, to develop the green technology for the controllable preparation and to explore the relationship between the bioactivity and its physical and chemical properties of pentosan sulfate to accelerate its practical application in medicine and biomaterials.
Keywords:Heparin; Pentosan; Pentosan sulfate; Biological activity; Green preparation; Application
Ph.D in Agriculture from Faculty of Agriculture, Tohoku University
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Professor, Chief Doctor, Director of Department of Pediatric Surgery, Associate Director of Department of Surgery, Doctoral Supervisor Tongji hospital, Tongji medical college, Huazhong University of Science and Technology
Senior Research Engineer and Professor, Center for Refining and Petrochemicals, Research Institute, King Fahd University of Petroleum and Minerals (KFUPM), Dhahran, Saudi Arabia
Fellow of International Agency for Standards and Ratings (IASR), Edith Cowan University, Sarich Neuroscience Research Institute
Chancellor Emeritus / Professor Emeritus of Chemistry and Physics, University of Missouri–St. Louis
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