Abstract

Single-cell RNA sequencing (scRNA-seq) has revolutionized biomedical research by describing and analyzing single-cell transcriptomes. scRNA-seq has identified unique cell types, analyzed single-cell trajectory generation and stem or progenitor cell growth, and compared healthy and diseased tissues at single-cell resolution. These applications have enhanced cardiovascular research, particularly abdominal aortic aneurysm treatment. Mammalian heart and blood vessel cell atlases, cardiovascular development, and stem/progenitor cell differentiation pathways illustrate this. This review discusses scRNAseq applications in AAA research and how basic AAA research might be applied to clinical practice.

Keywords:Single-cell RNA sequencing; Cardiovascular disease; Abdominal aortic aneurysm; Biomedical research