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Abstract

Research in Medical & Engineering Sciences

Droplet-Interfaced Separations as an Emerging Tool for High-Throughput Microchip Electrophoresis

  • Open or CloseSammerul Hassan1,2* Xunli Zhang1,2 and Xize Niu1,2

    1Mechanical Engineering, Faculty of Engineering and Physical Sciences, University of Southampton, UK

    2Institute for Life Sciences, University of Southampton, UK

    *Corresponding author:Sammerul Hassan, Institute for Life Sciences, University of Southampton, UK

Submission: July 22, 2019;Published: August 01, 2019

DOI: 10.31031/RMES.2019.08.000679

ISSN: 2576-8816
Volume8 Issue1

Abstract

Electrophoresis is a powerful analytical separation technique to analyses biological sample fragments such as nucleic acids, biomarkers, proteins, enzymes etc. Microchip electrophoresis (MCE) is a miniaturised form of electrophoresis and offers fast, robust and low-cost analyses and portability. However, the current format of MCE operates only in the single channel, which limits the throughput of the separations. Droplet-based microfluidics, on the other hand, offers simplicity, robustness and multiplicity in microchannels. Therefore, it has a great potential for droplet-based high throughput electrophoretic separations of DNA fragments, proteins and biomarkers from biofluids such as saliva, blood, dialysate etc. and the ease of operational procedures could further lead this for the Point-of-Care (POC) diagnostics in healthcare.

Keywords: Microchip electrophoresis; Electrophoresis; Droplet-interfaced separations; Gel electrophoresis; Droplet microfluidics

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