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Abstract

Research & Investigations in Sports Medicine

Hormetins: “The Dose Alone Makes the Poison” Thus “The Thing What Does Not Kill Us, Makes Us Stronger”

  • Open or Close Ceren Gezer*

    Department of Nutrition and Dietetics, Turkey

    *Corresponding author: Ceren Gezer, Department of Nutrition and Dietetics, Faculty of Health Sciences, Turkey.

Submission: November 05, 2018; Published: November 14, 2018

DOI: 10.31031/RISM.2018.04.000587

ISSN: 2577-1914
Volume4 Issue3

Abstract

Hormesis is “chemical and environmental factors having a beneficial effect to cells in an organism at low doses, whereas they are damaging at high doses”. The factors that trigger stress response pathways hormetically called as hormetin. Hormetins can be classified as physical hormetins (exercise, thermal shock and irrigation), psychological hormetins (mental interrogation and focusing), biological and nutritional hormetins (infections, nutrients, energy restriction) [1-4]. At molecular level stress response in mammalian cells can be classified as heat shock response, unfolded protein response, autophagic response, deoxyribonucleic acid (DNA) repair response, antioxidant response, sirtuin response and nuclear factor-kappa B (NF-κB) inflammatory response. Hormetins trigger these pathways thus strength the cell. According to this, body can improve its defensive system and retarding age-related chronic diseases such as neurodegenerative diseases, cardiovascular diseases, cancer, etc.

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