Abstract

Autoimmune Progesterone Dermatitis (APD), a disease with an incompletely defined epidemiology and pathogenesis, is increasingly reminiscent of itself. The most common triggers for the development of the disease are pregnancy, taking progesterone and combined oral contraceptives. The situation is aggravated by the fact that there are no definite criteria for its diagnosis, there is no understanding of what specialists should deal with these patients, and, ultimately, what effective therapy should be. In this article, we present a clinical case of APD in a young patient, which developed without any triggers before the implementation of the reproductive function, which impaired the quality of life. The oral contraceptive containing drospirenone, selected for the patient, made it possible to save her from the clinical manifestations of APD for a long period of time. Autoimmune progesterone dermatitis is a disease that occurs predominantly in women of reproductive age. At the same time, in the case of a severe course of the disease, therapy reaches the extirpation of the uterus with appendages and subsequent estrogen monotherapy, which is unacceptable in patients who have not yet realized their reproductive function. It is necessary to continue research in the field of the pathogenesis of this condition, as well as the search for possible methods of therapy and correction of symptoms.

Keywords: Autoimmune progesterone dermatitis; Progesterone; Drospirenone; Allergic reaction