Abstract

Paracetamol is one of the analgesic drugs that will give various side effects if it is taken in high doses. The popularity of hydrogels that release a drug in a temporal, spatial, and dosage-controlled manner has been fueled by recent advancements in polymer chemistry and drug delivery. The present article deals with the synthesis of hydrogel for paracetamol drug delivery. Hydrogels were prepared under mini review different ranges of pH and mixing volume ratios of polymer matrix monomer and crosslinkers as well (e.g., Starch, citric acid, crosslinking, and initiator, etc.). Physical properties like swelling percentage in distilled water and thermal stability have been analyzed to identify quality of prepared hydrogels. In-vitro study revealed the potential of starch-based hydrogels as biodegradable green material for drug delivery. These findings of reported studies revealed that starch-based hydrogels could be effectively employed for the drug delivery of pharmaceutical drug (paracetamol).

Keywords: Starch; Hydrogel; Paracetamol; Drug release