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Progress in Petrochemical Science

4,4-Dimethoxy-2-butanone as 1,3-Dielectrophylic 3-Carbon Building Block: New Route for the Synthesis of Toluene, o-Xylene, Naphthalenes and Pyrimidines

  • Open or Close Charanraj TP1, Ramachandra P2, Ramesh N3 and Junjappa H1*

    1Chemistry Research Unit, REVA Institute of Science and Management, India

    2Department of Chemistry, REVA Institute f Technology and Management, India

    3Director Planning, REVA University, India

    *Corresponding author: Junjappa H, Chemistry Research Unit, REVA Institute of Science & Management, Bangalore, India

Submission: July 12, 2018; Published: August 24, 2018

DOI: 10.31031/PPS.2018.02.000544

ISSN 2637-8035
Volume2 Issue4


4,4-dimethoxy-2-butanone 1 is shown to react with allyl magnesium chloride/allyl bromide in the presence of zinc to yield the corresponding toluene in 63% and 52% yields respectively. Similarly, crotyl bromide reacted with 1 in the presence of zinc to yield o-xylene in 32% yield. 1 was also reacted with benzyl magnesium chloride and phenyl acetonitrile to yield the corresponding naphthalenes in 53% and 61% yields respectively. The ketone 1 was reacted with guanidines to yield the corresponding pyrimidines in 58% and 66% yields respectively.

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