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Psychology and Psychotherapy: Research Study

The First Appearance of Persistent Dementia and Psychosis after a Generalized Sepsis

Submission: March 11, 2019;Published: March 25, 2019

DOI: 10.31031/PPRS.2019.02.000536

ISSN 2639-0612
Volume2 Issue3


Research suggests that neuroinflammation of the brain has a role in dementia by activating glial cells which then release proinflammatory agents and lipopolysaccharide (LPS) responsible for cognitive deficits [1-3]. Other authors suggest that there is no clear evidence if neuroinflammation after generalized infection is a cause, agent, or consequence of Alzheimer’s Disease (AD) with bacterial LPS acting on neurons and microglia [4,5]. The current case study refers to a 64-year old lady who developed symptoms of dementia and psychosis a month after she was operated for a duodenal perforation resulting in pneumoperitoneum and generalized bacterial sepsis. Neuropsychiatric and clinical assessment gathered the required data. Past psychiatric history was negative, and former cognitive deficits were non-existent before the systemic inflammation.

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