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Abstract

Open Access Biostatistics & Bioinformatics

Detection of protein complexes in blood plasma synthesized by malignant glioma cells and their microenvironment by dynamic light scattering depending on the degree of the blood-brain barrier permeability

Submission: April 03, 2020; Published: April 17, 2020

DOI: 10.31031/OABB.2020.03.000551

ISSN 2578-0247
Volume3 Issue1

Abstract

In the blood plasma of patients with malignant gliomas of the brain by method dynamic light scattering protein complexes with diameter of more than 150nm were detected, indicating increased permeability of the blood brain/tumor (BBTB) and blood-brain (BBB) barriers. The results of these studies are taken as the basis for the development of the express method for determining the increased permeability of the BBTB and BBB in neurosurgical patients. The method can be used at a certain stage of chemotherapy for patients with malignant gliomas of the brain, depending on the permeability of the BBTB and BBB.

Keywords: Dynamic light scattering method; Malignant gliomas of the brain; BBB; BBTB; Permeability; Express method

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