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Abstract
Open Access Biostatistics & Bioinformatics
Detection of protein complexes in blood plasma synthesized by malignant glioma cells and their microenvironment by dynamic light scattering depending on the degree of the blood-brain barrier permeability
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Open or CloseGridina NYa*1, Chunikhin AYu2, Morozov AN1, Rozumenko VD1, Draguntsova
NG1, Belousova AD1, Tarasov AL3, Beloshitsky VV1
1Institute of Neurosurgery n A P Romodanov NAMSU, Kiev, Ukraine
2Institute of Biochemistry n A V Palladin NASU, Kiev, Ukraine
3Institute of Cybernetics n V M Glushkov NASU, Kiev, Ukraine
*Corresponding author:Gridina N Ya, Institute of Neurosurgery n. A. P. Romodanov NAMSU, Kiev, Ukraine
Submission: April 03, 2020; Published: April 17, 2020
ISSN 2578-0247Volume3 Issue1
Abstract
In the blood plasma of patients with malignant gliomas of the brain by method dynamic light scattering protein complexes with diameter of more than 150nm were detected, indicating increased permeability of the blood brain/tumor (BBTB) and blood-brain (BBB) barriers. The results of these studies are taken as the basis for the development of the express method for determining the increased permeability of the BBTB and BBB in neurosurgical patients. The method can be used at a certain stage of chemotherapy for patients with malignant gliomas of the brain, depending on the permeability of the BBTB and BBB.
Keywords: Dynamic light scattering method; Malignant gliomas of the brain; BBB; BBTB; Permeability; Express method
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