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Novel Techniques in Nutrition and Food Science

Γ-H2ax Histone as a Biomarker of Medicinal Plants Genotoxicity: Technical Note

  • Open or CloseMélanie Poivre1,2*, Marie-Hélène Antoine1, Amandine Nachtergael2, Pierre Duez2 and Joëlle Nortier1

    1Laboratory of Experimental Nephrology, Faculty of Medicine, Université Libre de Bruxelles, Belgium

    2Laboratory of Therapeutic Chemistry and Pharmacognosy, Faculty of Medicine, Pharmacy and Biomedical Sciences, Research Institute for Health Sciences and Technology, University of Mons-UMONS, Belgium

    *Corresponding author:Poivre Mélanie, Laboratory of Experimental Nephrology, Faculty of Medicine, Université Libre de Bruxelles, Campus Erasme, 808 route de Lennik, 1070 Brussels, Belgium

Submission: January 31, 2024;Published: February 14, 2024

Volume7 Issue3
December , 2023


Natural products are generally considered as safe and reliable, whereas they could represent a real danger for public health. Indeed, many herbs are either directly reactive towards DNA or likely to disturb cellular homoeostasis, cell cycle and/or genome maintenance mechanisms. Genotoxicity refers to the deleterious effect of a chemical compound or a physical event on the genetic material. Such genotoxic events are considered hallmarks of cancer risk. In this technical note, discussions are held about manipulations involving the use of γ-H2AX as biomarker of genotoxicity through assessment of two medicinal plants involved in aristolochic acid nephropathy patients in Belgium: Aristolochia species and bark of Magnolia officinalis. γ-H2AX is increasingly considered as an attractive biomarker for either DNA damage or DNA repair. Moreover, the detection of γ-H2AX can potentially serve as a biomarker for transformation of normal tissue to malignant tissues in many cancers.

Keywords: Aristolochia; Magnolia; Genotoxicity; Apoptosis; Γ-H2AX histone; Aristolochic acids

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