Crimson Publishers Publish With Us Reprints e-Books Video articles

Abstract

Novel Research in Sciences

Synthesis and Anti-inflammatory Activity of Newly Synthesized 1,7-Dimethyl-4H-Benzo [D] [1,3]-Oxazin-4-One and 3-Amino-1,7- Dimethyl-Quinazolin-4(3H)-One

  • Open or ClosePeter Osarodion O*

    Department of Chemical Sciences, Nigeria

    *Corresponding author:Peter Osarodion O, Department of Chemical Sciences, Nigeria

Submission: February 22, 2021;Published: March 04, 2021

Abstract

Background/Introduction: The synthetic studies of 4-quinazolinone derivatives have been presented due to the chemical and biological interest. 4-Quinazolinone derivatives possesses antibacterial, antifungal, amti-inflammatory, analgesic activities.

Aims and objectives: The objective of the present study was to synthesize these quinazolinone derivatives 3-Amino 7-methyl-1-methyl-4H-benzo[d]-[1,3]-oxazin-4-one and 3-Amino-7-methyl-2- methyl-3H-quinazolin-4-one and screened them for their anti-inflammatory activity.

Materials and methods: The condensation of 2-amino-methyl-5-methylbenzoate with acetic anhydride yielded the cyclic compound 1, 1,7-dimethyl-4H-benzo[d]-[1,3]-oxazin-4-one which further produce a novel 2,3-disubstituted-quinazolin-4 ones via the reaction with hydrazine hydrate. The compounds synthesized were unequivocally confirmed by means of Infrared, Nuclear Magnetic Resonance (1H and 13C), Gas Chromatography Mass Spectrophotometer and Elemental analysis. The synthesized compounds were screened and pharmacologically screen them for their anti-inflammatory activity.

Conclusion: Compound 2 showed a higher anti-inflammatory activity against compared to compound [1].

Keywords: 1,7-Dimethyl-4H-benzo[d]-[1,3]-oxazin-4-one and 3-Amino-2,7-Dimethyl-3H-quinazolin-4- one; 2-amino-methyl-5-methylbenzoate; Nucleophile; Anti-inflammatory activity

Get access to the full text of this article


About Crimson

We at Crimson Publishing are a group of people with a combined passion for science and research, who wants to bring to the world a unified platform where all scientific know-how is available read more...

Leave a comment

Contact Info

  • Crimson Publishers, LLC
  • 555 Madison Avenue, 5th floor
  •     New York, NY 10022, USA
  • +1 (929) 600-8049
  • +1 (929) 447-1137
  • info@crimsonpublishers.com
  • www.crimsonpublishers.com