Abstract

Background/Introduction: The synthetic studies of 4-quinazolinone derivatives have been presented due to the chemical and biological interest. 4-Quinazolinone derivatives possesses antibacterial, antifungal, amti-inflammatory, analgesic activities.

Aims and objectives: The objective of the present study was to synthesize these quinazolinone derivatives 3-Amino 7-methyl-1-methyl-4H-benzo[d]-[1,3]-oxazin-4-one and 3-Amino-7-methyl-2- methyl-3H-quinazolin-4-one and screened them for their anti-inflammatory activity.

Materials and methods: The condensation of 2-amino-methyl-5-methylbenzoate with acetic anhydride yielded the cyclic compound 1, 1,7-dimethyl-4H-benzo[d]-[1,3]-oxazin-4-one which further produce a novel 2,3-disubstituted-quinazolin-4 ones via the reaction with hydrazine hydrate. The compounds synthesized were unequivocally confirmed by means of Infrared, Nuclear Magnetic Resonance (1H and 13C), Gas Chromatography Mass Spectrophotometer and Elemental analysis. The synthesized compounds were screened and pharmacologically screen them for their anti-inflammatory activity.

Conclusion: Compound 2 showed a higher anti-inflammatory activity against compared to compound [1].

Keywords: 1,7-Dimethyl-4H-benzo[d]-[1,3]-oxazin-4-one and 3-Amino-2,7-Dimethyl-3H-quinazolin-4- one; 2-amino-methyl-5-methylbenzoate; Nucleophile; Anti-inflammatory activity