Ethnic Differences in Genetic Immunity to Cancer

For many decades the ability of cancer to invade human body and subsist in it like a parasite was out of the main stream of the discoveries of the biology, epidemiology, genetics, immunology and pathogenesis of this disease. The ability to withstand the invasion by the means of immunity has been neglected too. The first evidences of genetic immunity against cancer have been received thank to pioneering both families and genealogical observations, that have been made at the beginning of XX Century. Warthin [1,2]. Unfortunately, these first evidences have been neglected and forgotten. Most recent data of genetic immunity against cancerous disease are presented. Main goal of this article is to present recent information about genetic immunity to cancer. ethnic differences in susceptibility to cancerous disease. The data about the subsistence of the disease in 125 ethnoses around the World have been analyzed.

The differences amongst 125 observed ethnic populations have been analyzed. Two main groups of populations have been revealed: the group of most immune populations and the group of most susceptible populations.

a) Most immune populations (Index of Mortality < 100)

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The data, that have been presented and analyzed above, are in quied accordance with the theory of invasive origin and parasite subsistence of human cancer [4]. According to data of evolutionary epidemiology, genetic immunity to infectious diseases is elaborated firstly in populations, that had more ancient confrontation with relevant epidemics. Analogous correlations are seen also in the case of genetic immunity to cancer. The above presented data are evidenced, that pandemics of cancerous disease started firstly amongst the populations of West Africa, Abyssinia and India. Most susceptible populations (west Europeans, Australian aborigines and Tasmanians) met the pandemics of cancer far later.

The differences amongst 125 observed ethnic populations have been analyzed. Two main groups of populations have been revealed: the group of most immune populations and the group of most susceptible populations. These new data have allowed us to conclude that revealed differences are of genetic i.e. of evolutionary origin, compatible to those ones, that have been discovered in the area of genetic immunity against infectious diseases. The above new notions provide framework and landmarks for the detection and discovery of genomic roots of cancer and encourage new proposals for its healing and prevention, as well as for the discovery of the origin and evolution of cancerous disease, as well as of its impact on both ancient and future evolution of humankind [5,6].

1. Warthin AS (1913) Hereditary with reference to carcinoma as shown by the study of the cases examined in the pathological laboratory of the university of michigan, 1895- 1913. Archives of Internal Medicine 12(5): 546-555.
2. Warthin AS (1925) The further study of a cancer family. J Cancer Research 9(2): 279-286.
3. Hauser J, Weller CV (1936) A further report on the cancer family of warthin. Am J Cancer 27(3): 434-450.
4. 1999-2007 Cancer Incidence and Mortality Data (2007) National program of cancer registries. Betesda, Maryland, USA CDC.
5. Rumyantsev SN (2018) Parasite subsistence of human cancer. Novel Approaches in Cancer 1(2): 1-15.
6. Rumyantsev SN (2008) Hereditary immunity: fundamental principles and exploitation in life study and health care. Nova Science Publishers, New York, USA, pp. 81-102.