1Chairman & CEO of New Vision Inc Taipei, Taiwan
2Graduate Institute of Applied Science and Engineering, Fu Jen Catholic University, Taiwan
3PhotoDynamic C0, Taiwan
4Department of Life Science, Fu Jen Catholic University, Taiwan
*Corresponding author: Jui-Teng Lin, Chairman and CEO of New Vision Inc, Taipei, Taiwan
Submission: October 06, 2018; Published: October 10, 2018
The role of oxygen, cell killing threshold dose and efficacy improvement of anti-cancer via type-II phototherapy are analyzed by both analytic formulas and numerical data. Higher initial photoinitiator (PS) concentration (C0) and/or light intensity (I0) has a faster efficacy, due to faster depletion of PS and oxygen concentration. Without the external oxygen supply, higher C0 or I0 produces more efficient singlet oxygen, resulting a higher transient efficacy, but they reach the same steady-state value when oxygen is completely depleted. With the external oxygen supply, higher efficacy (with no steady-state limitation), or lower cell viability are achieved. The overall efficacy may be enhanced by resupply of PS or oxygen during the light exposure.
Keywords: Modeling; Phototherapy; Kinetic; Anti-cancer; Singlet oxygen; Efficacy