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Novel Approaches in Cancer Study

Analysis the Role of Oxygen, Light Intensity, Threshold Dose and Efficacy Improvement of Anti-Cancer via Type-II Photodynamic Therapy

  • Open or Close Jui-Teng Lin1*, Kuo-Ti Chen2,3 and Hsia-Wei Liu4

    1Chairman & CEO of New Vision Inc Taipei, Taiwan

    2Graduate Institute of Applied Science and Engineering, Fu Jen Catholic University, Taiwan

    3PhotoDynamic C0, Taiwan

    4Department of Life Science, Fu Jen Catholic University, Taiwan

    *Corresponding author: Jui-Teng Lin, Chairman and CEO of New Vision Inc, Taipei, Taiwan

Submission: October 06, 2018; Published: October 10, 2018

DOI: 10.31031/NACS.2018.02.000533

Volume2 Issue1


The role of oxygen, cell killing threshold dose and efficacy improvement of anti-cancer via type-II phototherapy are analyzed by both analytic formulas and numerical data. Higher initial photoinitiator (PS) concentration (C0) and/or light intensity (I0) has a faster efficacy, due to faster depletion of PS and oxygen concentration. Without the external oxygen supply, higher C0 or I0 produces more efficient singlet oxygen, resulting a higher transient efficacy, but they reach the same steady-state value when oxygen is completely depleted. With the external oxygen supply, higher efficacy (with no steady-state limitation), or lower cell viability are achieved. The overall efficacy may be enhanced by resupply of PS or oxygen during the light exposure.

Keywords: Modeling; Phototherapy; Kinetic; Anti-cancer; Singlet oxygen; Efficacy

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